Food Allergies and Intolerance
Leben mit Nahrungsmittel-Allergie
|Allergen Data Collection:
Celery (Apium graveolens)
|Authors in alphabetical order [contact
IgE mediated reactions to celery are common in food allergic adults
in Europe. Sensitization to celery is frequently associated with birch
and/or mugwort pollinosis, hence the term "birch- mugwort- celery- syndrome"
has been established. There is evidence that birch pollen and celery allergy
are highly related in Central Europe, while celery allergy is most frequently
related to mugwort pollen in Southern Europe. Moreover, allergies to carrot
and spices, predominantly of the umbelliferous family, are highly associated
to celery allergy. Celery can induce allergic reactions of immediate type
from oral contact urticaria to anaphylactic shock. About 30% of patients
with oral allergy syndrome are allergic to celery.
Diagnostic tests like skin tests with raw celery and active allergen extracts have high positive predictive values, while the negative predictive values are low. Roots, also called tuber or celeriac, and sticks from the celery plant are used in nutrition and diagnostic procedures. Usually the frequency of sensitization to celery tuber is higher than to celery stick in celery allergic subjects. Celery tuber and stick are consumed as a raw or cooked vegetable and as a spice which is a common hidden allergen in various processed foods. Despite its high allergenic potency and at least partial thermostability celery and celery products are currently not included in mandatory labelling regulations for food allergens.
At least three groups of cross- reactive allergens have been identified in celery: 1. Bet v 1 homologous 16 kDa allergen (Api g 1) with IgE cross- reactivity to birch pollen, fruits, and vegetables (eg. apple and carrot), 2. The actin- binding panallergen profilin (Api g 4) with appr. 15 kDa, and 3. Allergens in the range of 30-70 kDa, including the recently described 55/58 kDa isoallergens (Api g 5) cross-reactive to birch pollen and mugwort pollen.
The present data collection reviews detailed information on the prevalence
and symptoms of celery allergy as well as cross- reactivities, and molecular
biological and allergenic properties of the major celery allergens in tabular
The reference lists of the Allergen Data Collections are based mainly on searches of Medline and FSTA (Food Science & Technology Abstracts) databases up to the related dates of publication. The scientific rigor of the studies listed is variable and not subject of critique or evaluation by the authors or the editor of the Allergen Data Collections. The reader should be aware of considerable problems in comparing data from different studies (eg. patient cohorts, diagnostic performances, possible flaws in allergen preparations and methodologies for allergen characterization) and is encouraged to review the original publications.
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